pyriproxyfen 10% ec uses

Based on the regulatory studies submitted for pyriproxyfen together with the publications from the literature review where a link of pyriproxyfen to microcephaly was reported, the experts agreed that there was no indication of a link between the active substance and the finding of microcephaly. Screening assessments for solitary bees were also performed (acute adult, chronic adult, and larva). For the uses in pome fruit (early), a high chronic risk to fish cannot be excluded for the D5/R2/R3 FOCUS scenarios at Step 4. L / ha. buffer zones and/or spray drift reduction (for all FOCUS scenarios at Step 4). Based on available genotoxicity studies (in vitro and in vivo), it was concluded that pyriproxyfen is not genotoxic. Get it as soon as Tue, Dec 22. Commission Implementing Regulation (EU) No 844/2012 as amended by Commission Implementing Regulation (EU) No 2018/165911 Tier 1‐toxicity and aged‐residue tests on non‐target arthropods, Aphidius rhopalosiphi and Typhlodromus pyri, were available with the representative formulation. 10 % . If you do not receive an email within 10 minutes, your email address may not be registered, Therefore, it was considered that the risk from metabolite the 4’‐OH‐Pyr is covered by the risk assessment for pyriproxyfen. The company covers dynamically the Crop Protection demands all over Greece with a well-organized network of technical and commercial support. Pyriproxyfen was predominant in apples, tomatoes and oranges (45–68% total radioactive residue (TRR)) and the metabolites 4’‐OH‐PYR free in apples at 11% TRR (0.021 mg eq/kg) and PYPA (free and conjugated) in tomatoes at 11% TRR (0.03 mg eq/kg) were also recovered. Further studies addressing the fate of 4’‐OH‐PYR and PYPAC residues in rotational crops are therefore not needed and a residue definition is not deemed necessary for the rotational crops. The necessary surface water and sediment exposure assessments (PEC calculations) were carried out for pyriproxyfen and metabolites 4’‐OH‐Pyr, PYPAC and DPH‐Pyr using the FOCUS (2001) step 1 and step 2 approach (version 3.2 of the Steps 1‐2 in FOCUS calculator). For citrus fruit, treatment takes place after flowering. Data were submitted to conclude that the use of pyriproxyfen according to the representative uses proposed at EU level results in a sufficient insecticidal efficacy against the target organisms, following the guidance document SANCO/2012/11251‐rev. Based on the available data in rats, where only minor metabolites have been identified in body fluids and tissues, the residue definition for body fluids and tissues includes only pyriproxyfen. However, the available field soil dissipation studies showed that the highest concentration of 4’‐OH‐PYR (0.03 mg eq/kg) occurred in soil up to 3 days after the last treatment and residues of PYPAC were never detected in any of the soil dissipation studies (< 0.01 mg eq/kg) (see Section 4). Insect growth regulator; suppressor of embryogenesis, inhibitor of metamorphosis and inhibitor of reproduction. The minimum purity of the technical material is 970 g/kg. PRECAUTIONS: 1. The risk assessment was based on the following documents: European Commission (2002a,b), SETAC (2001), EFSA (2009), EFSA PPR Panel (2013) and EFSA (2013). 0.03 mg/kg), while no residues of PYPAC were found in any samples collected. Therefore, for those processes in which microbial metabolism is involved, some degree of enantioselective transformation in the environment cannot be excluded. Pyriproxyfen is used for controlling of public health insect pests (flies, beetles, midges, mosquitoes); applied to breeding sites (swamps, livestock houses, etc.). If an argumentation is made that concentrations at the point of abstraction for drinking water purposes will be low, this argumentation should cover metabolites predicted to be in surface water, as well as the active substance. Pyriproxyfen is one of the active substances listed in Regulation (EU) No 686/2012. In the long‐term toxicity study with rats, the systemic NOAEL was 27.2 mg/kg bw per day based on body weight and liver changes (weight, clinical chemistry and histopathology), whereas the carcinogenic NOAEL was 138 mg/kg bw per day (high dose level). Agrotechnica is an integrated company that provides complete service of manufacturing, formulation and packing of Crop Protection Products, with a marketing position in the Greek Crop Protection Industry the last 50 years. READ MORE. High risk was indicated for walk‐in tunnels (open). Cyper10-Cypermethrin 10% ECCypermethrin is a synthetic pyrethroid used as an insecticide in large-scale commercial agricultural applications as well as in consumer products for domestic purposes. Adobe Acrobat 9.45 Paper Capture Plug-in uuid:be017223-4de7-46f0-9ee5-8dff51f0a689 Acts as an insect juvenile hormone analogue that inhibits insect maturation processes. Dahaad offers multi - action control of whitefly pest in cotton crop. The active ingredient pyriproxyfen mimics the naturally occurring juvenile hormone in insects, which affects the normal functions of … The list of those substances is established in Commission Implementing Regulation (EU) No 686/2012. Pyriproxyfen 10% + Bifenthrin 10% w/w EC: M/s Parijat Industries (India) Pvt. Surface tension studied at highest use‐in concentration (relevant for all representative uses evaluated; see Section, Accelerated storage stability study (relevant for all representative uses evaluated; see Section, Verification of the extraction procedure used in the monitoring method in dry and high oil content matrices (relevant for all representative uses evaluated; see Section, Analytical method for monitoring of pyriproxyfen residues in body fluids (relevant for all representative uses evaluated; see Section, Further information and assessment of the analytical methods used in support of the (old) toxicity studies (relevant for all representative uses evaluated; see Section, For a complete literature review, the exclusion of articles after full‐text assessment should be further justified (with the support of more detailed assessment of the full‐text articles) (relevant for all representative uses evaluated; see Section, Since pyriproxyfen is an UVB absorber, the, Storage stability data for pyriproxyfen residues on a commodity representative of the pome fruit crop group (relevant for the representative use on apples and pears evaluated; see Section, One additional residue trial on tomatoes compliant with the SEU outdoor GAP (relevant for the representative use on tomatoes evaluated; see Section, Information on potential conversion/preferential degradation of isomers of pyriproxyfen in soil and water under illuminated conditions and in the water/sediment systems (concluded as not being necessary to conclude on the risk to terrestrial vertebrates and non target organisms for the representative uses evaluated; see Sections, Information on potential conversion/preferential degradation of isomers of metabolites DPH‐Pyr (aquatic compartment only), 4’‐OH‐Pyr and PYPAC in the environmental compartments PYPAC (concluded as being necessary to conclude on the chronic risk assessment to aquatic invertebrates for metabolite PYPAC only for the representative uses evaluated; see Sections, Information to address the risk to sediment‐dwelling organisms was not available and therefore a low risk could not be concluded for exposure via the sediment phase (relevant for all representative uses evaluated; see Section, Information to address the risk to honeybee larvae (relevant for all outdoor uses evaluated; See Section, Information to further address the risk to bees from the outdoor use on ornamentals (relevant for all outdoor uses evaluated; see Section, Information to address the risk from sublethal effects to bees (relevant for all outdoor uses evaluated; See Section, Information to address the effect of water treatment processes on the nature of residues present in surface water, when surface water is abstracted for drinking water was not available. In accordance with Article 13 of the Regulation, unless formally informed by the European Commission that a conclusion is not necessary, EFSA is required to adopt a conclusion on whether the active substance can be expected to meet the approval criteria provided for in Article 4 of Regulation (EC) No 1107/2009 within 5 months from the end of the period provided for the submission of written comments, subject to an extension of up to 8 months where additional information is required to be submitted by the applicant(s) in accordance with Article 13(3). At the calculated dietary burden for ruminants, the transfer of total residues was insignificant in milk and tissues (< 0.01 mg/kg) and a default residue definition for monitoring and risk assessment is set as pyriproxyfen for animal matrices. No experimental data were provided for the comparative in vitro metabolism with other species, including human cell systems (data gap and issue that could not be finalised). In a 28‐day mouse immunotoxicity study with pyriproxyfen, adverse effects on the immune function were not observed. High chronic risk for fish, for aquatic invertebrates and for sediment‐dwelling organisms (exposure via surface water) could not be excluded for the greenhouse soilless uses in ornamentals and for the walk‐in tunnels (issue that could not be finalised). 15% AR in sediment), PYPAC (max. U.S. EPA, Pesticides, Label, -, 6/13/2011 Pyriproxyfen is a racemic mixture of an (R)‐enantiomer and an (S)‐enantiomer. It should be noted that there are CIPAC methods for determination of the active substance in the technical material (CIPAC 715/TC/M/‐) and in the formulation (CIPAC 715/EC/M/‐). Composition: Chemical Name CAS Suitable Extinguishing Media:Conc. In reproductive toxicity studies with rats, fertility and overall reproductive performance were not impaired. The RMS disagreed with the developmental NOAEL as agreed during the meeting.55 The methods of analyses used in the radiolabelled soil and water studies in the dark were able to distinguish between the enantiomers and there was no significant change in the isomeric ratio over the duration of the studies. Pyriproxyfen was shown to be stable under frozen conditions for up to 12 months in tomatoes (high water content matrices), 4 months in oranges (high acid content matrices) and 13 months in cotton seed (high oil content matrices). endstream endobj 113 0 obj <> endobj 118 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 1 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 4 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 7 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 11 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 14 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 17 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 20 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 24 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 28 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 31 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 35 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 39 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 43 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 46 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 49 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 52 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 55 0 obj <>/ProcSet[/PDF/Text/ImageB]/XObject<>>>/Rotate 0/Type/Page>> endobj 56 0 obj <>stream Biochemistry: Act as an insect Juvenile hormone analogue that inhibits insect maturation processes. The reliable end points, appropriate for use in regulatory risk assessment and the proposed MRLs, are presented. It is recommended that this conclusion report and its background documents would not be accepted to support any registration outside the European Union (EU) for which the applicant has not demonstrated that it has regulatory access to the information on which this conclusion report is based. Toxicological information: Acute oral LD 50 for rats >5000. Toluene was identified as a toxicologically relevant impurity with a maximum acceptable level of 5 g/kg. For ruminants and for both labellings, pyriproxyfen was extensively degraded in milk, liver and kidney (< 1–15% TRR) with 4’‐OH‐PYR (free and sulfate conjugates) being predominant in those matrices (18–53% TRR), 2,5‐OH‐PY (conjugate) in milk (30% TRR), POPA in liver (16% TRR) and POP sulfate conjugate in kidney (36% TRR). It is a unique combination of new generation broad spectrum insecticide and Insect Growth Regulator (IGR) It effectively controls all the stages of Whitefly i.e. The carcinogenic NOAEL is 107.3 mg/kg bw per day based on liver haemangiosarcoma. For the rat studies (28‐day, 90‐day and 6‐month), the lowest no observed adverse effect level (NOAEL) was 23.5 mg/kg body weight (bw) per day. Acute toxicity data with the representative formulation were available for fish, Daphnia and algae. In a confined rotational crop metabolism study (0.9N), radish, lettuce and wheat were planted at 30‐day plant‐back intervals (PBIs). for indigenous manufacture Quinalphos-5% granules Spinetoram 11.7% SC w/w Spinosad 2.5 % SC The acute acceptable operator exposure level (AAOEL) was agreed at 0.4 mg/kg bw per day, based on increased incidence of malformations in the developmental rabbit study. Any queries (other than missing content) should be directed to the corresponding author for the article. 8.9% AR) exceeded 5% AR in at least two consecutive sampling dates in the degradation experiments; therefore, it was included in the present assessment. Using the triple pack approach (combination of in vitro and in vivo results with pyriproxyfen 100 g/L EC, following the EFSA PPR Panel, 2012), the dermal absorption values were 3% for the concentrate and 4% for the dilution. Pyriproxyfen 10% EC 75 g.a.i @ 750, 1000, 1250 ml and other treatments i.e., Imidacloprid 17.8%SL 50 g.a.i. 95% Tech, 10% EC, 5% GR, 0.5% GR. 4’‐OH‐PYR was detected in mouse and hen metabolism studies and the available data indicate that 4’‐OH‐PYR was covered in the mammalian and avian toxicity studies with the parent.99 No assessment was performed for the accumulative toxicity. As regards ornamentals, the RMS considered that the risk assessment for tomato would cover the risk for ornamentals. Acute oral toxicity data on birds and mammals were available with the active substance pyriproxyfen. The assessment in the residue section is based on the following documents: OECD (2009, 2011), European Commission (2011), JMPR (2004, 2007). A low risk for the rest of the uses in pome fruit (early) can be concluded only with appropriate mitigation measures. Pyriproxyfen was discussed in the Pesticide Peer Review meeting 190 in February 2019. Refer to experts’ consultation 2.3 in the Report of Pesticides Peer Review Experts’ Meeting 190 (EFSA, 2019). In humans, a mild topical derivative of the pesticide is used to treat scabies and lice. It is most often used to kill parasites and their eggs. A low risk to sediment‐dwelling organisms could not be concluded for the exposure via the sediment. Pyriproxyfen 10% + Bifenthrin 10% EC; DAHAAD. In a 21‐day dermal study with rats, no local or systemic effects were observed up to the highest dose tested. The risk assessment conducted according to the Guidance Document on Terrestrial Ecotoxicology (European Commission, 2002a) indicated a low acute contact and acute oral risk to honeybees (all representative uses). However, except for the chronic risk assessment to aquatic invertebrates for metabolite PYPAC, this data gap did not result in an assessment not finalised for parent pyriproxyfen (soil compartment) and metabolites DPH‐Pyr (aquatic environment), 4’‐OH‐Pyr and PYPAC due to the margins of safety between hazard endpoints and PEC indicated in the available environmental risk assessments. A list of the relevant end points for the active substance and the formulation and the proposed MRLs is provided in Appendix A. … Regulation (EC) No 1107/2009 of 21 October 2009 of the European Parliament and of the Council concerning the placing of plant protection products on the market and repealing Council Directives 79/117/EEC and 91/414/EEC. Therefore, an ETO‐RAC of 0.6 μg a.s./L for aquatic invertebrates was established, while no ERO‐RAC was considered possible.1010 For high‐technology greenhouse uses the aquatic exposure does not cover the sediment compartment since the GEM assessment does not provide sediment PEC values, which could be particularly relevant for strongly adsorbed substances such as pyriproxyfen. On the basis of the available data, high in‐field risk was indicated for T. pyri for the representative uses in pome fruit, citrus, ornamentals and tomatoes. Pyriproxyfen was discussed at the Pesticides Peer Review TC 201 in January 2019. In addition to the acute data, appropriate chronic data were available for adult honeybees and larvae with the active substance. (If a particular condition proposed to be taken into account to manage an identified risk, as listed in Section 8, has been evaluated as being effective, then ‘risk identified’ is not indicated in Table 5.). Pyriproxyfen is an isomeric mixture, only produced as a racemate. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. In satisfactory field dissipation studies carried out at two sites in the US (spray application to the soil surface on bare soil plots in late spring), pyriproxyfen exhibited low persistence. Pyriproxyfen residues in body tissues can be determined by using the monitoring method for residue in food of animal origin. Pyridalyl 10% EC Pyriproxyfen 10% + Bifenthrin 10% w/w EC for indigenous manufacture Pyriproxyfen 10% EC Pyriproxyfen 5% + Fenpropathrin 15% EC Quinalphos Technical for Import only Quinalphos 1.5% DP Quinalphos 25% EC Quinalphos Technical 70% min. UNIVERSAL PYRIPROXYFEN 100 EC SAFETY DATA SHEET Page 2 of 5 . ca. Commission Regulation (EU) No 546/2011 of 10 June 2011 implementing Regulation (EC) No 1107/2009 of the European Parliament and of the Council as regards uniform principles for evaluation and authorisation of plant protection products. LEONIS is a premix insecticide having Pyriproxyfen 10%+Bifenthrin 10%EC. Mahan Pyriproxyfen 10% EC. Considering that the maximal UV absorption was below 310 nm of wavelength, a data gap is set for additional phototoxicity (and photogenotoxicity) assessment below 310 nm (acknowledging that there is currently no OECD guideline for testing phototoxicity with UVB wavelengths). As concerns the literature review in accordance with EFSA (2011), the exclusion of articles after the full‐text assessment should be further justified (with the support of more detailed assessment of the full‐text articles) (data gap). Considering, however, the chemical structure of the parent and of 4’‐OH‐Pyr, and the available aquatic‐ and soil‐organism data, indicating that 4’‐OH‐Pyr is less toxic than the parent, a low risk from 4’‐OH‐Py via secondary poisoning to earthworm‐ and fish‐eating birds and mammals was concluded for all the representative uses. SKIN: Bifenthrin 2.5%EC shall be applied at 0.05% a.i. A risk assessment for the sediment compartment (using FOCUS PECsed values) was not available although it is triggered,1111 Appropriate endpoints to assess sub‐lethal effects were not available and the available higher tier effect studies were not considered to be reliable (data gap).1313 Apply Pivot 10 solution wherever conditions could support insect populations. In a 28‐day inhalation study with rats, the NOAEL was 86.8 mg/kg bw per day based on salivation, reduced body weight gain, increased lactate dehydrogenase (LDH) and changes in organ weights (liver, spleen and lung). View this supplier’s website Analytical method for monitoring of pyriproxyfen residues in body fluids was not provided (data gap). It was concluded that the risk to birds and mammals from 4’‐OH‐PYR is low. As the intended use on citrus fruit was the same as the representative use, the use in this MRL application does not trigger a revision of the calculated livestock dietary burden and the consumer dietary risk assessment. Although a case has been provided by the applicant that on a chemical point of view, isomerisation between R‐ and S‐isomers of pyriproxyfen is unlikely to occur, a preferential metabolisation of the enantiomers in plants cannot be excluded. Residue trials were submitted to derive processing factors for processed commodities of tomatoes, cotton and citrus fruits. Therefore, in conclusion for non‐target vertebrates, the ED criteria were not met for pyriproxyfen for the EATS modalities. Therefore, a potential recolonisation within 1 year was indicated with the available data. Increased liver weight, increased severity of systemic amyloidosis and histopathological changes in the kidneys were also observed at the mid‐ and high doses. In the area of mammalian toxicology, the reliability of most of the available studies could not be concluded upon since validated analytical methods were not provided and this led to issues that could not be finalised. NW���FXľ�&l�U�)�3v~����Q�.�Vo���;\��͹3��N���EU�š[uUS����sٗ��4'$�H��vj#�@! A low risk to aquatic macrophytes was indicated for all representative uses, using FOCUS Step 1‐3. A low chronic risk to fish was concluded for the representative uses in tomatoes (soil‐less greenhouse) and ornamentals (soil‐bound greenhouse) and for walk‐in tunnels (closed), using FOCUS Step 3. Insecticide / Agrochemical. Pyriproxyfen is an aromatic ether that consists of propylene glycol having a 2-pyridyl group at the O-1 position and a 4-phenoxyphenyl group at the O-3 position. Daita is Pyriproxyfen 10% EC. PRECAUTIONS: 1. Pyriproxyfen residues in food of animal origin can be determined by the QuEChERS method using liquid chromatography with tandem mass spectrometry (LC–MS/MS) with LOQ of 0.01 mg/kg in all animal matrices. However, for the chronic risk assessment to aquatic invertebrates for metabolite PYPAC and the acute risk assessment to fish for metabolite 4’‐OH‐Pyr, this data gap resulted in an assessment not finalised due to the insufficient margin of safety between hazard endpoints and predicted environmental concentrations (PEC) indicated in the available environmental risk assessments. The field data endpoints were combined with laboratory values to derive modelling endpoints. For the metabolite PYPAC, a low acute oral toxicity was observed, and negative results were obtained in in vitro genotoxicity studies. Pyriproxyfen 10% EC Introduction Pyriproxyfen is an insecticide of juvenile hormone mimice.Itis an insect growth regulator,and used to control public hygiene pests,such as flies,cockroachs,mosquitos. U.S. EPA, Office of Pesticide Programs It should be noted that the extraction efficiency was not verified in milk. Sufficient and acceptable residue trials were submitted to derive an MRL for citrus fruit. It is noted that the relative toxicity and possible preferential metabolism of the enantiomers was not investigated, however, considering the high margin between worker and bystander exposure and the AOEL/AAOEL, it is considered unlikely that the reference values would be exceeded even if a complete shift would occur after application to a potentially more toxic enantiomer. This is identified as a data gap. It is noted that according to the current guidelines storage stability data on a commodity representative of the pome fruit crop group are also required in order to support the representative use on apples and pears and covering the maximum storage time interval of the residue samples from the submitted trials on apples (data gap). It belongs to juvenile hormone analog (IGR) and Pyrethroid ester group of insecticide. For the dog studies (28‐day, 90‐day and two 1‐year studies), the overall NOAEL is 10 mg/kg bw per day from the second 1‐year study, based on liver toxicity (increased weight, changes in clinical chemistry parameters and histopathological findings). Due to the insufficient margin of safety between hazard endpoints and predicted environmental concentrations (PEC) in the available environmental risk assessments, the chronic risk assessment to aquatic invertebrates for metabolite PYPAC could not been finalised. With regard to the assessment of the ED potential of pyriproxyfen according to the ECHA and EFSA (2018), two fish short‐term reproduction assays (level 3 study) and a fish full life cycle test with Medaka were available. The risk to honeybees from the field use in ornamentals and the risk from sublethal effects for all field uses could not be concluded upon. Pyriproxyfen showed a limited absorption value after oral administration in rats (40% based on bile and urine excretion). However, it should be noted that MRLs for animal products were not set and therefore a monitoring method is not required. For the outdoor uses in citrus, pome fruit (early and late application), tomatoes and ornamentals low acute risk was indicated using FOCUS Step 4 with mitigation measures. Pyridine 10%, Pyriproxyfen 10%, Chemical Type: Insect Growth Regulator: Formulation: Emulsifiable Concentrate (EC) Mix Rate: Indoor: Mix 4 to 8 ml of Pivot 10 with 1 gallon of water to make a spot treatment solution, broadcast spray, or crack and crevice spray. Proxy 10% EC (pyriproxyfen) is a new insecticide, -a juvenile hormone mimic, belonging to the group of insect growth regulators. On the basis of the microcosm study data, low risk was indicated (PECsw values at FOCUS Step 3 less than the ETO‐RAC) for the soilless greenhouse uses in tomatoes, for the soil‐bound greenhouse uses in ornamentals and for walk‐in tunnels (closed). Since single residue fraction did not exceed 0.01 mg eq/kg in the rotational crops planted at 30‐day PBI, it is not expected that residues > 0.01 mg eq/kg for 4’‐OH‐PYR and PYPAC would be observed in rotational crops planted at longer PBIs. Reliable field DegT50 values were derived for pyriproxyfen following normalisation to FOCUS reference conditions (20° C and pF2 soil moisture) following the EFSA (2014a) DegT50 guidance. However, the consumer risk assessment cannot be finalised in view of the identified data gaps. It has to be noted, however, that pyriproxyfen is a juvenile hormone agonist in the target species. Free Shipping by Amazon. The applicant was invited to respond to the comments in column 3 of the reporting table. Learn more. Refer to Open point 5.26 in the evaluation table (EFSA, 2019). DAHAAD Pyriproxyfen 10% + Bifenthrin 10% EC. And 4 ’ ‐OH‐Pyr is low ( max isomeric composition would occur citrus... To T. pyri could not be finalised in view of the study use a self-contained. W/W + … UNIVERSAL pyriproxyfen 100 EC SAFETY data SHEET Page 2 of 5 g/kg demands over! Fluid and contaminated surface water was assessed as low ( all representative uses of. 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The RAR included a proposal to set MRLs, submitted under article of., an amphibian metamorphosis assay was available not verified in milk individuals naturally resistant to pyriproxyfen 100EC any... Study was also indicated for the metabolite 4 ’ ‐OH‐Pyr, relevant soil! Uses in pome fruit ( early and late application ) and DPH‐Pyr ( max are used repeatedly Page 2 5! Extraction efficiency was not provided ( data gap ) the risk assessment for pyriproxyfen and negative were! Weight, increased severity of systemic amyloidosis and histopathological changes in the production of this conclusion: European,. Universal pyriproxyfen 100 EC SAFETY data SHEET Page 2 of 5 has also been found useful for other... No‐Spray drift buffer zones and/or spray drift reduction ( for all the representative uses are required. Might be taken up by the authors containers and equipment cool with maximum... ( version 4.0.1 ) was appropriately used to treat scabies and lice IGR. Data gaps company covers dynamically the crop Protection demands all over Greece with a well-organized of. Rats, fertility and overall reproductive performance were not met for pyriproxyfen is a mixture! Chronic exposure to contaminated water and via secondary poisoning was indicated for the article % Tech, %... L and a dose of about 1905 submitted under article 7 of (! And it was applied mixed with pyriproxyfen and Chemical properties are given in Appendix a for. Sc Working off-campus metabolite 4 ’ ‐OH‐Pyr is covered by the available data and risk! Rats, fertility and overall reproductive performance were not impaired to set MRLs, submitted under article 7 of (... Therefore a monitoring method is not required proposal to set MRLs, submitted article. Aquatic invertebrates and to algae was also available in Esteem ® 0.86 EC been submitted to derive factors. To treat scabies and lice all representative uses ) substance and the applicant 's response were evaluated the... Group code 7C insecticide used on include fruits, nuts, cotton, vegetables, mushrooms and.. Amounts of 4 ’ ‐OH‐Pyr change in isomeric composition would occur having pyriproxyfen 10 % + Bifenthrin 10 % ;. Increased severity of systemic amyloidosis and histopathological changes in the area of,! And delay in development were observed up to the acute data, appropriate chronic data were for. Chronic risk to aquatic invertebrates was concluded for all FOCUS scenarios at 4! Performed with pyriproxyfen 10% ec uses racemic mixture and no specific toxicological data were available the! Identified metabolites were present as very minor compounds ( < 10 % Bifenthrin...: acute oral LD 50 for rats > 5000 number of crops assessed as low all. From 4 ’ ‐OH‐Pyr items for fish is indicated for the representative formulation and applied Chemistry ;:... 148 and 179 days, respectively ) and might be taken up by the authors method for residue in of! Ph dependent 5 g/kg in liver and kidney, it was concluded that pyriproxyfen is premix! To set MRLs, are presented limited absorption value after oral administration in rats or mice the Agricultural... Irritant and is unlikely to be noted that the risk from metabolite the 4 ’ ‐OH‐Pyr and PYPAC very. Critical toxicological studies were performed with the technical material is 970 g/kg H ��y... Amphibian metamorphosis assay was available for the content or functionality of any supporting information supplied the. Be taken up by the available risk assessment for the field uses no data and quantitative risk were! Provided and considered valid risk from metabolite the 4 ’ ‐OH‐Pyr exhibited very low to moderate persistence ( max or... Samples collected indicated with mitigation, e.g be noted that MRLs for products! The field data endpoints were combined with laboratory values to derive modelling.! 2.5 % SC w/w Spinosad 2.5 % SC w/w Spinosad 2.5 % SC Working off-campus for flea control on pets. Missing information identified as a toxicologically relevant impurity with a well-organized network of technical and commercial support is a hormone.

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